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OCR: in MS. B, ca. 1487-90.) These include statements about the vigorous circulation of a healthy city: "One needs a fast-flowing river to avoid corrupt air produced by stagnation, and this will also be useful for regularly cleansing the city when opening its sluices." The analogy that Leonardo made between the microcosm of the human body and the macrocosm of the city is indebted to the architectural theory of Vitruvius. Many other artists drew on this theory, including Leonardo's friend Francesco di Giorgio